![]() ![]() ![]() Thus, alpha-2 agonists may act on a final common pathway of stress-induced and possibly cue-induced relapse ( 14), which are relevant with multiple drugs of abuse. Among the clinically available medications, alpha-2 adrenoceptor agonists such as lofexidine, guanfacine, and clonidine ( 9, 10) selectively block stress-induced reinstatement of heroin, cocaine, alcohol, and nicotine seeking ( 9– 13). In search of such a treatment, we turned to findings from the rat reinstatement model, in which extinguished drug seeking resumes after exposure to a stressor, a drug cue, or a priming dose of drug ( 7, 8). Buprenorphine maintenance might be improved with the addition of a treatment that specifically buffers the effects of one or more triggers. Relapses, briefer lapses, and episodes of craving can be triggered by acute precipitants: stress, exposure to drug-associated cues, or the use of an initially small amount, or priming dose, of drug ( 5, 6). Despite effective treatments for opioid addiction (e.g., buprenorphine and methadone) ( 1), patients still relapse to opioid misuse ( 2– 4). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |